Staphylococcus epidermidis Infection

Staphylococcus epidermidis is a coagulase-negative, gram-positive cocci bacteria that form clusters. It is also a catalase-positive and facultative anaerobe. They are the most common coagulase-negative Staphylococcus species that live on the human skin. In its natural environments such as the human skin or mucosa, they are usually harmless. Many times, these coagulase-negative staph species invade the human body via prosthetic devices, at which point a small number of microbes travel down the prosthetic device to the bloodstream. The bacteria, then, can produce biofilms that help to protect them from host defense or antimicrobials.

The belief is that Staphylococcus epidermidis is one of the most common causes of nosocomial infection, with infection rates as high as those of Staphylococcus aureus.

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Conflict of interest statement

Disclosure: Ezra Lee declares no relevant financial relationships with ineligible companies.

Disclosure: Fatima Anjum declares no relevant financial relationships with ineligible companies.

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References

    1. Hamory BH, Parisi JT, Hutton JP. Staphylococcus epidermidis: a significant nosocomial pathogen. Am J Infect Control. 1987 Apr;15(2):59-74. - PubMed
    1. Zheng CX, Ma XF, Zhang YH, Li HJ, Zhang GF. [Research progress in the mechanism of translation initiation of eukaryotic mRNAs]. Yi Chuan. 2018 Aug 16;40(8):607-619. - PubMed
    1. Lax S, Gilbert JA. Hospital-associated microbiota and implications for nosocomial infections. Trends Mol Med. 2015 Jul;21(7):427-32. - PubMed
    1. Otto M. Staphylococcus epidermidis--the 'accidental' pathogen. Nat Rev Microbiol. 2009 Aug;7(8):555-67. - PMC - PubMed
    1. Kleinschmidt S, Huygens F, Faoagali J, Rathnayake IU, Hafner LM. Staphylococcus epidermidis as a cause of bacteremia. Future Microbiol. 2015;10(11):1859-79. - PubMed